How cells control RNA messages after they're made
Post-transcriptional Regulatory Networks
Researchers are mapping how proteins bind and regulate RNA to help explain genetic changes that can cause cancers and neurological conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11099745 on NIH RePORTER |
What this research studies
Researchers will run lab tests that measure how hundreds of proteins stick to different RNA sequences, then use artificial intelligence to learn the rules of those interactions. They plan to predict where regulatory RNA elements sit in human genes and how mutations might change those interactions. The team will share their data, software, and web tools so doctors and scientists can look up whether a patient’s mutation may disrupt RNA regulation. This work is done in the lab and on computers, not as a clinical treatment.
Who could benefit from this research
Good fit: The project does not enroll patients, but its results will be most relevant to people with cancers or genetic neurological disorders that involve mutations affecting RNA-binding proteins.
Not a fit: Patients with health problems unrelated to gene or RNA regulation are unlikely to see any direct benefit from this project.
Why it matters
Potential benefit: If successful, this could help clinicians and geneticists predict which mutations disrupt RNA regulation and guide diagnosis or future targeted treatments.
How similar studies have performed: This builds on established laboratory RNA-binding assays and prior machine-learning models that have successfully mapped many protein–RNA interactions, but scaling to all human RBPs is ambitious and partly novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Morris, Quaid — Sloan-Kettering Inst Can Research
- Study coordinator: Morris, Quaid
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.