How cells control protein production through translation initiation
Diverse and dynamically regulated mRNP composition regulating translation
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11006295
This study looks at how cells decide which proteins to make and how much of them to produce, which could help us find new ways to treat diseases caused by problems with protein production.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11006295 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which cells regulate the initiation of protein synthesis, focusing on how different factors influence which proteins are produced and in what quantities. By examining the formation of translation initiation complexes and their regulation by various signaling pathways, the study aims to uncover the dynamic nature of protein synthesis in response to cellular needs. Patients may benefit from insights gained into how these processes can be manipulated to address diseases related to protein synthesis dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with diseases linked to protein synthesis abnormalities.
Not a fit: Patients with conditions unrelated to protein synthesis regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions caused by improper protein synthesis.
How similar studies have performed: Other research has shown promising results in understanding translation initiation, suggesting that this approach has the potential for significant advancements.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INGOLIA, NICHOLAS T — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: INGOLIA, NICHOLAS T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.