How cells control protein production through translation initiation
Official title: Diverse and dynamically regulated mRNP composition regulating translation
Funded at University of California Berkeley · NIH-11006295 · Data updated 2026-11-12
This study looks at how cells decide which proteins to make and how much of them to produce, which could help us find new ways to treat diseases caused by problems with protein production.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $268,480 |
| NIH project number | 5R01GM139008-03 |
| Project ID | NIH-11006295 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with diseases linked to protein synthesis abnormalities.
✕Less likely to help
Patients with conditions unrelated to protein synthesis regulation may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which cells regulate the initiation of protein synthesis, focusing on how different factors influence which proteins are produced and in what quantities. By examining the formation of translation initiation complexes and their regulation by various signaling pathways, the study aims to uncover the dynamic nature of protein synthesis in response to cellular needs. Patients may benefit from insights gained into how these processes can be manipulated to address diseases related to protein synthesis dysregulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions caused by improper protein synthesis.
How similar studies have gone: Other research has shown promising results in understanding translation initiation, suggesting that this approach has the potential for significant advancements.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Ingolia, Nicholas T — University of California Berkeley
- Study coordinator: Ingolia, Nicholas T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.