How cells control protein amounts and modifications using proteogenomics
Illuminating Post-Transcriptional Regulation through Proteogenomic Integration
This work combines protein measurements with genetic and RNA information to find how cells control protein levels and modifications, which could help people with diseases linked to faulty proteins.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11091181 on NIH RePORTER |
What this research studies
Researchers will merge large-scale protein data with DNA and RNA data to map the networks that act after genes are transcribed, including ribosomes, RNA-binding proteins, and the proteasome. They will develop new laboratory and computational tools to link genetic differences to changes in protein abundance and post-translational modifications. The project uses samples across tissues and organisms and modern proteomics methods to build comprehensive maps of post-transcriptional regulation. The resulting data and tools are intended to help other scientists find protein biomarkers and targets for future diagnostics and therapies.
Who could benefit from this research
Good fit: People with conditions known to involve protein misregulation—such as certain cancers, neurodegenerative diseases, or muscle disorders—or those willing to contribute tissue or blood samples could be relevant to this work.
Not a fit: Patients seeking an immediate treatment change or those whose conditions do not involve protein regulation are unlikely to see direct short-term benefits.
Why it matters
Potential benefit: If successful, this work could reveal new protein-based biomarkers and therapeutic targets for diseases caused by protein dysregulation.
How similar studies have performed: Proteogenomics has produced promising links between genetic changes and protein-level effects in some areas, but comprehensive maps of post-transcriptional regulation and genetic effects on protein modifications are still relatively new.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Huang, Kuan-Lin — Icahn School of Medicine at Mount Sinai
- Study coordinator: Huang, Kuan-Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.