How cells control hormones that affect blood pressure
Temporal coordination of stimulus-induced gene expression by RNA-binding proteins
This research looks at how special proteins help our adrenal glands make hormones like aldosterone, which is important for managing blood pressure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11138755 on NIH RePORTER |
What this research studies
Our bodies need to respond quickly and precisely to signals, and this involves carefully timed gene activity within cells. This project explores how certain proteins, called RNA-binding proteins, manage the exact timing of these cellular responses. We are focusing on human adrenal cells, which produce hormones like aldosterone that regulate blood pressure. By understanding how these proteins control the production of aldosterone in response to signals like Angiotensin II, we hope to uncover fundamental mechanisms. This knowledge is crucial for understanding how our bodies maintain balance and react to changes, especially concerning hormone-related conditions.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals interested in the basic mechanisms behind adrenal gland function, hormone production, and blood pressure regulation.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of blood pressure regulation and potential new ways to manage conditions like high blood pressure related to aldosterone.
How similar studies have performed: While the role of RNA-binding proteins in gene regulation is known, this specific focus on their temporal coordination in human adrenal steroidogenesis offers a novel approach to understanding blood pressure hormones.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Mukherjee, Neelanjan — University of Colorado Denver
- Study coordinator: Mukherjee, Neelanjan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.