How cells control gene messages and circular RNAs
Regulatory roles for the Integrator complex and circular RNAs
This research explores how our cells precisely control the messages made from our genes, including special circular RNA molecules.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11097220 on NIH RePORTER |
What this research studies
Our genes must create RNA messages that are correctly produced and processed for our cells to function properly. This project looks at two important ways cells manage these messages: a group of proteins called the Integrator complex and unique circular RNA molecules. Researchers want to understand how the Integrator complex can stop gene messages early, which is crucial for regulating gene activity. They also aim to uncover the functions of circular RNAs, which are different from typical linear RNA messages.
Who could benefit from this research
Good fit: This basic science research does not involve direct patient participation, but its findings could inform future studies for patients with conditions related to gene expression or RNA processing.
Not a fit: Patients seeking immediate new treatments or clinical trial opportunities would not directly benefit from this foundational laboratory work.
Why it matters
Potential benefit: This foundational knowledge could help us understand the root causes of many diseases linked to gene expression problems and potentially lead to new therapeutic strategies in the future.
How similar studies have performed: This project builds upon recent discoveries by the research team, suggesting a strong foundation for the proposed work.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Wilusz, Jeremy E — Baylor College of Medicine
- Study coordinator: Wilusz, Jeremy E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.