How cells communicate through membrane contact sites during development and disease
Composition and Function of Membrane Contact Sites in Differentiation and Disease
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11011015
This study is looking at how certain areas in our cells help them work together, especially when stem cells turn into nerve and muscle cells, and it hopes to find ways to improve our understanding of diseases that affect brain and body health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11011015 on ClinicalTrials.gov |
What this research studies
This research investigates the role of membrane contact sites (MCSs) in the coordination of cellular activities, particularly during the differentiation of stem cells into neurons and skeletal muscle. By using advanced imaging techniques, the researchers aim to understand how these sites change and function in different cell types. The study will also explore the interactions between lipid droplets and other organelles, which are crucial for cellular metabolism and health. Patients may benefit from insights gained into the mechanisms underlying neurodegenerative diseases and other conditions linked to cellular communication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative disorders or those interested in stem cell therapies.
Not a fit: Patients with acute injuries or conditions unrelated to cellular differentiation or communication may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases and improving cellular health.
How similar studies have performed: Previous research has shown promising results in understanding cellular communication and its implications for various diseases, indicating that this approach has potential for success.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COHEN, SARAH — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: COHEN, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.