How cells change their metabolism to produce reactive oxygen and nitrogen species.
Metabolic rewiring coupled to the production of reactive oxygen and nitrogen species (RONS)
This study looks at how immune cells change the way they use energy to help fight inflammation and send signals in the body, focusing on a special molecule they need to do this, and it's for anyone interested in understanding how our immune system works better during times of stress or illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morgridge Institute for Research, INC. NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10857238 on NIH RePORTER |
What this research studies
This research investigates how certain cells, particularly immune cells, alter their metabolism to produce reactive oxygen and nitrogen species (RONS), which play crucial roles in inflammation and signaling. The study focuses on understanding the mechanisms behind this metabolic shift, specifically how the activation of enzymes that produce RONS increases the demand for a molecule called NADPH. By exploring these processes, the research aims to uncover how cells can quickly adapt their energy production pathways to meet the increased metabolic needs during immune responses and other physiological functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory disorders or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to oxidative stress or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to inflammation and oxidative stress, such as cardiovascular diseases and neurodegenerative disorders.
How similar studies have performed: Previous research has shown that understanding metabolic changes in cells can lead to significant advancements in treating related diseases, indicating a promising avenue for this investigation.
Where this research is happening
Madison, United States
- Morgridge Institute for Research, INC. — Madison, United States (Active)
Researchers
- Principal investigator: Fan, Jing — Morgridge Institute for Research, INC.
- Study coordinator: Fan, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.