How cells change their behavior without genetic mutations
Official title: Post-transcriptional regulation of cell plasticity
Funded at Emory University · NIH-11086067 · Data updated 2026-11-12
This study is looking at how cells can change their behavior in response to their surroundings without changing their DNA, which could help us understand how conditions like cancer and immune responses work better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 21, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $380,261 |
| NIH project number | 5R35GM150760-03 |
| Project ID | NIH-11086067 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions influenced by cellular plasticity, such as certain cancers or immune disorders.
✕Less likely to help
Patients with stable genetic conditions that do not involve cellular plasticity may not benefit from this research.
What this research studies
This research investigates how cells can alter their characteristics in response to environmental changes without undergoing genetic mutations. It focuses on understanding the post-transcriptional mechanisms, such as mRNA modifications and translational control, that regulate protein synthesis and influence cell behavior. By exploring the role of the eukaryotic initiation factor 3 (eIF3) in translation regulation, the research aims to uncover how these processes contribute to cellular plasticity, particularly in complex diseases like cancer and immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases by targeting the mechanisms that allow cells to change their behavior.
How similar studies have gone: While the role of transcriptional regulation in cell behavior is well-studied, the specific focus on post-transcriptional mechanisms like eIF3 in cellular plasticity is relatively novel and has not been extensively tested.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Khoshnevis, Sohail — Emory University
- Study coordinator: Khoshnevis, Sohail
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.