How cells build their internal parts, like those involved in diabetes
Official title: MECHANISMS OF ORGANELLE BIOGENESIS AT THE ENDOPLASMIC RETICULUM SUBDOMAINS
Funded at University of Tennessee Knoxville · NIH-11127744 · Data updated 2026-11-12
This project aims to understand how cells create their internal structures, called organelles, which is important for conditions like adult-onset diabetes and Cerebro-Hepato-Renal Syndrome.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $376,892 |
| NIH project number | 5R35GM147189-04 |
| Project ID | NIH-11127744 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational laboratory work does not directly involve patient participation but could inform future treatments for individuals with adult-onset diabetes or Cerebro-Hepato-Renal Syndrome.
✕Less likely to help
Patients not affected by conditions related to organelle biogenesis, such as adult-onset diabetes or Cerebro-Hepato-Renal Syndrome, would not directly benefit from this specific research.
What this research studies
Our cells contain tiny compartments called organelles, each with a specific job. This project focuses on how cells build new organelles, especially those called peroxisomes and lipid droplets, which are linked to certain diseases. We are looking closely at special areas within a cell's network, called the endoplasmic reticulum, where these new organelles begin to form. By studying these processes in yeast and human cells, we hope to uncover the basic steps involved in their creation.
Why it matters
Potential benefit: Understanding these fundamental cellular processes could eventually lead to new ways to address disorders like adult-onset diabetes and Cerebro-Hepato-Renal Syndrome.
How similar studies have gone: This research builds upon previous findings that identified key proteins involved in organelle formation at specific cellular locations.
Where this research is happening
-
University of Tennessee Knoxville
Knoxville, United States Active
Researchers
- Principal investigator: Joshi, Amit — University of Tennessee Knoxville
- Study coordinator: Joshi, Amit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.