How cells build organelles from special ER regions
Official title: MECHANISMS OF ORGANELLE BIOGENESIS AT THE ENDOPLASMIC RETICULUM SUBDOMAINS
Funded at University of Tennessee Knoxville · NIH-11360196 · Data updated 2026-11-12
Scientists are studying how cells create new organelles like peroxisomes and lipid droplets from specialized regions of the endoplasmic reticulum, using yeast and human cell models to understand this basic biology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $376,780 |
| NIH project number | 5R35GM147189-05 |
| Project ID | NIH-11360196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for direct patient participation in this grant.
✕Less likely to help
No direct benefit to patients in the current research plan is expected; it focuses on basic cell biology.
What this research studies
This grant explores where in the ER new organelles form and which proteins and lipids are involved, using yeast and mammalian cell cultures. By mapping the proteins Pex30, MCTP1, and MCTP2 at ER subdomains, researchers aim to reveal how nascent organelles emerge. The work combines unbiased and targeted approaches to identify key players in organelle biogenesis and how these processes might relate to human disease. The findings could illuminate fundamental cell biology and point toward future therapies for conditions tied to organelle dysfunction.
Why it matters
Potential benefit: A deeper understanding of how cells build essential organelles could lead to new strategies for treating diseases related to organelle defects.
How similar studies have gone: Prior work has shown specific ER subdomains are sites of nascent organelle formation, supporting a promising path for this line of inquiry.
Where this research is happening
-
University of Tennessee Knoxville
Knoxville, United States Active
Researchers
- Principal investigator: Joshi, Amit — University of Tennessee Knoxville
- Study coordinator: Joshi, Amit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.