How cells build important structures called peroxisomes
Targeting of proteins into peroxisomes
This project aims to understand how cells create tiny compartments called peroxisomes, which is important for people with certain genetic disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11123918 on NIH RePORTER |
What this research studies
Our bodies rely on tiny cell parts called peroxisomes to function properly, and problems with how they are made can lead to serious health conditions. This project uses yeast, a simple model, to uncover the basic steps involved in creating these peroxisomes. By finding new genes and processes, we hope to gain a deeper understanding of how these essential cell parts are formed. This knowledge is crucial for improving our understanding of disorders where peroxisomes don't work correctly.
Who could benefit from this research
Good fit: This foundational research is relevant to patients and families affected by peroxisome biogenesis disorders.
Not a fit: Patients without peroxisome biogenesis disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding and diagnosis of peroxisome biogenesis disorders, potentially paving the way for new treatments.
How similar studies have performed: This project builds upon over three decades of successful research into peroxisome biogenesis, while also introducing a novel screening method.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Subramani, Suresh — University of California, San Diego
- Study coordinator: Subramani, Suresh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.