How cells break down noncoding RNAs
Destruction of noncoding RNAs
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11134629
Researchers are learning how cells destroy tiny noncoding RNAs that help control genes, work that could matter for people with cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11134629 on ClinicalTrials.gov |
What this research studies
This laboratory project focuses on how two types of noncoding RNAs—microRNAs and circular RNAs—are tagged and degraded inside cells. The team will study target-directed miRNA degradation (TDMD), how binding of highly complementary RNAs leads to ubiquitination of the Argonaute protein, and how the proteasome contributes to Argonaute and miRNA loss. Experiments will use molecular and biochemical methods in cell lines to find the endogenous RNA targets and protein effectors that drive destruction. The goal is to map the pathways that control RNA stability and understand how their failure may contribute to cancer.
Who could benefit from this research
Good fit: This grant supports basic laboratory research and does not enroll patients or require human participants.
Not a fit: Patients seeking immediate treatments or clinical trial enrollment will not benefit directly from this lab-focused research.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets for cancer diagnostics or therapies that control harmful gene-regulating RNAs.
How similar studies have performed: Previous studies, including findings from the PI, have shown examples of TDMD and identified an E3 ligase, but broadly identifying endogenous TDMD targets is still a new area.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KLEAVELAND, BENJAMIN MONTEVERDE — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: KLEAVELAND, BENJAMIN MONTEVERDE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers