How cells adjust their energy production to meet changing needs
Cellular mechanisms of bioenergetic plasticity
This study is looking at how muscle and nerve cells change the way they produce energy to do their jobs better, which could help us find new treatments for conditions like diabetes and Leigh syndrome where energy production goes wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10854880 on NIH RePORTER |
What this research studies
This research investigates how different types of cells, such as muscle and nerve cells, adapt their energy production processes to support their functions. By using advanced imaging techniques and genetic analysis, the researchers aim to uncover the molecular mechanisms that allow cells to fine-tune their metabolism. This understanding is particularly important for conditions like diabetes and Leigh syndrome, where energy metabolism is disrupted. The goal is to identify new pathways that could be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders such as diabetes or Leigh syndrome.
Not a fit: Patients with unrelated conditions or those not experiencing metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders by enhancing our understanding of energy regulation in cells.
How similar studies have performed: Other research has shown promising results in understanding metabolic regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ashrafi, Ghazaleh — Washington University
- Study coordinator: Ashrafi, Ghazaleh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.