How cells adjust their chromatin structure in response to low oxygen levels.
Official title: Regulation of SWI/SNF chromatin remodeler composition and function.
Funded at University of Rhode Island · NIH-10730626 · Data updated 2026-11-12
This study is looking at how a special group of proteins in our cells changes when there's not enough oxygen, which can help us understand how these changes might affect cancer and other diseases, ultimately aiming to improve treatments for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $455,630 |
| NIH project number | 1R15GM151701-01 |
| Project ID | NIH-10730626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cancers that are influenced by hypoxia or chromatin remodeling.
✕Less likely to help
Patients with conditions unrelated to chromatin remodeling or hypoxic responses may not receive any benefit from this research.
What this research studies
This research investigates how different forms of the SWI/SNF chromatin remodeler complex change in response to low oxygen conditions, known as hypoxia. By examining how these complexes alter gene expression, the study aims to understand the dynamic regulation of chromatin architecture in normal cells. The researchers will analyze the composition of these complexes and their roles in responding to environmental stimuli, which could provide insights into cancer biology and other diseases. Patients may benefit from a better understanding of how cellular responses to hypoxia can influence cancer progression and treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer by manipulating chromatin remodeling in response to hypoxic conditions.
How similar studies have gone: Previous research has shown that understanding chromatin remodeling in response to environmental changes can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Rhode Island
Kingston, United States Active
Researchers
- Principal investigator: Dutta, Arnob — University of Rhode Island
- Study coordinator: Dutta, Arnob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.