How cells add and change RNA tails in health and disease
Decode polyadenylation in health and disease
This project looks at how cells add and alter the tail ends of RNA messages to help explain conditions like cancer and some inherited blood disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11261738 on NIH RePORTER |
What this research studies
Researchers will map where and how cells add poly(A) tails to mRNA and how often different tail choices are used. They will combine laboratory work (including cancer cell lines and experimental models) with analysis of human genetic and tissue samples to see how DNA changes affect this process. The team will examine the enzyme CPSF73 and test how blocking it with compounds like JTE-607 changes RNA processing in lab models. Results aim to link specific genetic variants and pathways to disease mechanisms and suggest targets for future diagnostics or treatments.
Who could benefit from this research
Good fit: People with cancers, inherited blood disorders such as alpha/beta thalassemia, or related immune conditions who can provide blood or tissue samples would be the most relevant candidates.
Not a fit: Patients whose conditions are unrelated to RNA polyadenylation mechanisms or who cannot provide samples are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could reveal new diagnostic markers and drug targets that lead to better treatments for cancers and some inherited blood or immune disorders.
How similar studies have performed: Preclinical work has shown that CPSF73 inhibitors like JTE-607 can affect cancer and inflammation, but predicting polyadenylation outcomes from DNA sequences is still largely unproven.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Shi, Yongsheng — University of California-Irvine
- Study coordinator: Shi, Yongsheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.