How cells adapt to low oxygen by changing their energy production methods
Official title: Function, regulation, and conservation of hypoxia-induced glycolysis condensates
Funded at Johns Hopkins University · NIH-11061921 · Data updated 2026-11-12
This study looks at how cancer cells change the way they produce energy when there's not enough oxygen, by organizing special structures that help them survive and grow; the goal is to find new ways to improve cancer treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $439,512 |
| NIH project number | 5R35GM148248-03 |
| Project ID | NIH-11061921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with solid tumors that experience hypoxic conditions.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by hypoxia may not benefit from this research.
What this research studies
This research investigates how cells, particularly in cancerous environments with low oxygen, adapt their energy production by organizing glycolysis enzymes into specialized structures called G bodies. These G bodies help cells survive and proliferate under hypoxic conditions by enhancing glycolytic activity. The study uses biochemical techniques to analyze the components of these structures and explores the signaling pathways that regulate their formation. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for improving cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cancer treatment by targeting the metabolic adaptations of tumor cells.
How similar studies have gone: Other research has shown success in understanding cellular adaptations to hypoxia, but the specific focus on G bodies in this context is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Kim, John — Johns Hopkins University
- Study coordinator: Kim, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.