How cells adapt to low nutrient environments
Cellular Adaptations to Nutrient-Limited Metabolic Microenvironments
This study is looking at how cells manage to survive and grow when there aren’t enough nutrients, like in the brain and bone marrow, and it hopes to find new ways to help treat diseases that can be affected by these nutrient shortages, such as autoimmune and heart conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906350 on NIH RePORTER |
What this research studies
This research investigates how cells survive and grow in environments where nutrients are limited, such as in the brain and bone marrow. It focuses on identifying small molecules that can inhibit the metabolic adaptations cells use to thrive under these conditions. By understanding these adaptations, the research aims to discover new metabolites and metabolic pathways that could be targeted for therapeutic purposes. Patients may benefit from insights into how nutrient limitations contribute to various diseases, including autoimmune and cardiac conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from autoimmune diseases, cardiac disorders, or cancers that may be influenced by nutrient availability.
Not a fit: Patients with conditions unrelated to metabolic adaptations or nutrient limitations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by nutrient depletion and hypoxia.
How similar studies have performed: Other research has shown promise in targeting metabolic vulnerabilities in cancer and autoimmune diseases, suggesting that this approach could be effective.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Pacold, Michael Edward — New York University School of Medicine
- Study coordinator: Pacold, Michael Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.