How cells adapt to harmful environmental agents
Protein Modification and Stability Regulation to Cope with Genotoxic Environments
This study looks at how cells, like those in our bodies, deal with harmful things like pollution and radiation that can cause damage, using yeast to learn more about the proteins that help fix DNA and keep cells healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10996289 on NIH RePORTER |
What this research studies
This research investigates how human cells cope with harmful environmental agents like pollutants and radiation that can cause mutations and diseases. It focuses on understanding the molecular strategies cells use to survive these genotoxic conditions, particularly through error-prone repair mechanisms and the DNA damage checkpoint system. By using budding yeast as a model organism, the research aims to uncover the roles of specific proteins in DNA repair and cell cycle regulation when exposed to genotoxic stress. This could lead to insights into how similar processes might function in human cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to DNA repair deficiencies or those at risk of diseases caused by environmental genotoxic agents.
Not a fit: Patients who do not have any genetic predisposition to DNA repair issues or who are not exposed to significant environmental genotoxic agents may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular responses to environmental stressors, potentially leading to new therapeutic strategies for diseases caused by DNA damage.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Chwat-Edelstein, Tzippora — Weill Medical Coll of Cornell Univ
- Study coordinator: Chwat-Edelstein, Tzippora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.