How cells adapt to harmful environmental agents
Official title: Protein Modification and Stability Regulation to Cope with Genotoxic Environments
Funded at Weill Medical Coll of Cornell Univ · NIH-10996289 · Data updated 2026-11-12
This study looks at how cells, like those in our bodies, deal with harmful things like pollution and radiation that can cause damage, using yeast to learn more about the proteins that help fix DNA and keep cells healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31ES036884-01 |
| Project ID | NIH-10996289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA repair deficiencies or those at risk of diseases caused by environmental genotoxic agents.
✕Less likely to help
Patients who do not have any genetic predisposition to DNA repair issues or who are not exposed to significant environmental genotoxic agents may not benefit from this research.
What this research studies
This research investigates how human cells cope with harmful environmental agents like pollutants and radiation that can cause mutations and diseases. It focuses on understanding the molecular strategies cells use to survive these genotoxic conditions, particularly through error-prone repair mechanisms and the DNA damage checkpoint system. By using budding yeast as a model organism, the research aims to uncover the roles of specific proteins in DNA repair and cell cycle regulation when exposed to genotoxic stress. This could lead to insights into how similar processes might function in human cells.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular responses to environmental stressors, potentially leading to new therapeutic strategies for diseases caused by DNA damage.
How similar studies have gone: Other research has shown success in understanding DNA repair mechanisms in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Chwat-Edelstein, Tzippora — Weill Medical Coll of Cornell Univ
- Study coordinator: Chwat-Edelstein, Tzippora
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.