How cells adapt their energy production to meet changing needs
Cellular mechanisms of bioenergetic plasticity
This study looks at how different types of cells, like muscle and nerve cells, manage their energy production to do their jobs better, which could help us understand and improve conditions like diabetes and Leigh syndrome.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11115312 on NIH RePORTER |
What this research studies
This research investigates how different types of cells, such as muscle fibers and neurons, adjust their energy production to support their functions. By using advanced imaging techniques and genomic analysis, the researchers aim to uncover the molecular mechanisms that allow cells to fine-tune their metabolism. This understanding is particularly important for conditions like diabetes and Leigh syndrome, where energy metabolism is disrupted. The study focuses on how energy is produced in specific parts of the cell, which could lead to new insights into cellular health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders such as diabetes or Leigh syndrome.
Not a fit: Patients with conditions unrelated to metabolic dysfunction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders by improving our understanding of how cells manage their energy needs.
How similar studies have performed: Other research has shown promising results in understanding metabolic regulation in cells, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ashrafi, Ghazaleh — Washington University
- Study coordinator: Ashrafi, Ghazaleh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.