How cell structures manage fat and methionine levels
Official title: Subcellular mechanisms coupling lipid synthesis and methionine metabolism
Funded at Wayne State University · NIH-11074600 · Data updated 2026-11-12
This study is looking at how tiny connections between different parts of cells help control important processes like fat production and a nutrient called methionine, which are vital for keeping our cells healthy, especially when they face stress, and it uses yeast to learn more about how these connections might affect conditions like metabolic and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $370,480 |
| NIH project number | 5R35GM150892-03 |
| Project ID | NIH-11074600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders, neurodegenerative diseases, or age-related conditions that may be linked to lipid metabolism.
✕Less likely to help
Patients with conditions unrelated to lipid metabolism or methionine metabolism may not benefit from this research.
What this research studies
This research investigates the role of inter-organelle membrane contact sites (MCSs) in regulating lipid synthesis and methionine metabolism, which are crucial for cellular health. By using yeast as a model, the study explores how these contact sites influence the availability of S-adenosyl methionine (SAM), a key molecule in lipid biosynthesis and cellular functions. The research aims to understand the impact of MCS dysregulation on metabolic and neurodegenerative disorders, particularly in response to environmental stress. Through this approach, the study seeks to uncover new insights into how cells adapt to changes and maintain balance in lipid and methionine levels.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic and neurodegenerative disorders by targeting lipid and methionine metabolism.
How similar studies have gone: Previous studies have shown promising results in understanding the role of membrane contact sites in cellular metabolism, indicating that this research builds on established findings.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Hariri, Hanaa — Wayne State University
- Study coordinator: Hariri, Hanaa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.