How cell signals guide early human development
The Role of Hippo-Yap1 Signaling in Germ-layer Specification
['FUNDING_R01'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-11094766
This research explores how specific signals direct the very first stages of human development, which could help us understand and prevent birth defects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11094766 on ClinicalTrials.gov |
What this research studies
Our bodies begin as a single cell that divides and organizes into different layers, which then form all our organs and tissues. This project uses human stem cells in a lab to create tiny models of early human development. We are focusing on specific signals, like YAP and NODAL, that tell these cells what to become. By understanding how these signals work, we hope to learn why development sometimes goes wrong, leading to birth defects.
Who could benefit from this research
Good fit: This foundational research is relevant to families and individuals concerned with the causes and prevention of birth defects.
Not a fit: Patients not interested in the basic biological mechanisms of early human development may not find direct benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat and prevent birth defects by understanding the earliest stages of human development.
How similar studies have performed: This project builds upon ongoing studies and existing data, suggesting a progressive approach to understanding these complex biological processes.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ESTARAS, CONCEPCION — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: ESTARAS, CONCEPCION
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.