How cell signaling affects diseases through G protein-coupled receptors
Cell signaling by G protein-coupled receptors
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11082626
This study is looking at how certain proteins in our cells, called GPCRs, help send signals that can affect our health, especially in diseases like vascular inflammation, and it aims to find new ways to treat these conditions by understanding how these proteins work inside and outside of cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11082626 on ClinicalTrials.gov |
What this research studies
This research investigates the role of G protein-coupled receptors (GPCRs) in cellular signaling and their implications in various diseases. It focuses on understanding how these receptors function not only at the cell surface but also within the cell's interior, particularly in endosomes. By exploring the regulatory mechanisms that control GPCR signaling, the research aims to uncover how disruptions in these pathways can lead to disease progression, especially in conditions like vascular inflammation. The study will identify key proteins involved in this signaling process and their potential as therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to vascular inflammation or other diseases influenced by GPCR signaling.
Not a fit: Patients with conditions unrelated to GPCR signaling or vascular inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to GPCR signaling, improving patient outcomes.
How similar studies have performed: Previous research has shown success in targeting GPCRs for drug development, indicating a promising avenue for further exploration.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TREJO, JOANN — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: TREJO, JOANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer progression