How cell signaling affects diseases through G protein-coupled receptors
Cell signaling by G protein-coupled receptors
This study is looking at how certain receptors in our cells, called GPCRs, work and how problems with them might lead to diseases like vascular inflammation, so that we can find new ways to improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11055989 on NIH RePORTER |
What this research studies
This research investigates the role of G protein-coupled receptors (GPCRs) in cellular signaling and their implications in various diseases. The study focuses on how these receptors function not only at the cell surface but also within the cell, particularly in endosomes. By exploring the regulatory mechanisms that control GPCR signaling, the research aims to uncover how disruptions in these pathways contribute to disease progression, especially in conditions like vascular inflammation. Patients may benefit from insights gained into new therapeutic targets for existing drugs that modulate GPCR activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by GPCR signaling, such as cardiovascular diseases or inflammatory disorders.
Not a fit: Patients with conditions unrelated to GPCR signaling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for diseases linked to GPCR signaling.
How similar studies have performed: Previous research has shown success in targeting GPCRs for drug development, indicating a promising avenue for further exploration.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Trejo, Joann — University of California, San Diego
- Study coordinator: Trejo, Joann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.