How cell parts communicate and affect conditions like blindness
Mechanism and effects of communication between actin and gene regulatory complexes
This project aims to understand how tiny parts inside our cells communicate to control our genes, which could help us learn more about diseases like blindness and nerve problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10873365 on NIH RePORTER |
What this research studies
Our cells have internal structures, like the actin cytoskeleton, that help them move and maintain shape, and gene regulatory complexes that turn genes on and off. We've found that these two systems, which seem very different, actually talk to each other. When this communication goes wrong, it can lead to serious health issues, including problems with the nervous system and even blindness. By understanding how these systems interact, we hope to uncover new ways to address these conditions.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals affected by or at risk for nervous system degeneration and blindness.
Not a fit: Patients whose conditions are not related to the fundamental cellular mechanisms of actin and gene regulation may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into the causes of nervous system degeneration and blindness, potentially leading to new strategies for treatment.
How similar studies have performed: This project builds upon a recent discovery of crosstalk between these cellular complexes, suggesting a novel area of investigation.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Mohan, Ryan David — Wayne State University
- Study coordinator: Mohan, Ryan David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.