How cell organization affects diseases like ALS and cancer
Cell Organization Through Phase Separation: Mechanisms, Functions and Disease
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10897210
This study is looking at how tiny clusters of molecules in our cells affect important processes and diseases like neurodegeneration, cancer, and skin disorders, with the hope that understanding these clusters better will help improve treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10897210 on ClinicalTrials.gov |
What this research studies
This research investigates how biomolecular condensates, which are clusters of macromolecules in cells, play a role in various biological processes and diseases. By studying the mechanisms of phase separation, the research aims to understand how these condensates form and function, particularly in relation to neurodegeneration, cancer, and skin disorders. The approach includes examining the interactions and modifications that regulate these condensates, as well as their impact on cellular signaling and gene expression. Patients may benefit from insights gained into how these processes contribute to their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases, cancers, or skin disorders that may be linked to aberrant biomolecular condensates.
Not a fit: Patients with conditions unrelated to cellular organization or those not affected by neurodegenerative diseases, cancers, or skin disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases like ALS and cancer by targeting the mechanisms of cell organization.
How similar studies have performed: Previous research has shown promising results in understanding the role of biomolecular condensates in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSEN, MICHAEL K — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: ROSEN, MICHAEL K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease, Cancers