How cell nuclei squeeze and change when cells move through tight spaces
Nuclear mechanobiology in confined migration
This project looks at how the cell's nucleus changes when cells squeeze through tight spaces, which could matter for people with wounds, inflammatory conditions, or cancers that spread.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11262804 on NIH RePORTER |
What this research studies
Scientists will use 3D lab models and advanced microscopes to watch cells move through narrow spaces and see how the nucleus deforms. They will measure effects on the nuclear envelope, DNA damage, chromatin organization, and changes in gene activity. The team will manipulate nuclear stiffness and track whether repeated squeezing selects for cells that move more easily. The work uses cell and tissue models in the lab rather than testing treatments in people.
Who could benefit from this research
Good fit: People affected by cancers that spread, chronic wounds, or inflammatory conditions might be most interested in following this research or in future opportunities to donate tissue samples.
Not a fit: This project is basic laboratory research, so patients seeking immediate clinical treatments are unlikely to receive direct benefit from participation.
Why it matters
Potential benefit: If successful, this work could point to new ways to prevent harmful cell migration such as cancer metastasis or to improve tissue repair by targeting nuclear mechanics.
How similar studies have performed: Prior laboratory work has shown that nuclear deformation can cause envelope rupture and DNA damage, but translating those findings into patient therapies remains largely untested.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Lammerding, Jan — Cornell University
- Study coordinator: Lammerding, Jan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.