How cell metabolism controls exosome production
Metabolic regulation of exosome biogenesis
This work looks at how changing cell metabolism affects the number and contents of exosomes—tiny packages cells release that can carry signals or therapies—and how that could help people with acquired brain injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11162386 on NIH RePORTER |
What this research studies
Researchers will change nutrient and NAD levels in cells to see how those shifts affect how many exosomes cells release and what molecules they carry. They will develop a method to sort and analyze single exosomes so they can identify which carry specific therapeutic or diagnostic cargo. The team will study exosomes from mesenchymal stem cells and from biofluids like blood to link metabolic states with exosome markers relevant to brain injury. Results are intended to guide better ways to produce therapeutic exosomes and to develop blood-based markers for monitoring brain injury.
Who could benefit from this research
Good fit: Adults with acquired brain injury (for example traumatic brain injury or stroke) who can provide blood or urine samples and consent to sample use would be the most likely candidates to contribute data or samples.
Not a fit: People without brain injury or those needing immediate clinical treatment are unlikely to receive any direct clinical benefit from this lab-focused research.
Why it matters
Potential benefit: If successful, this work could lead to better blood tests for brain injury and improved methods to make therapeutic exosomes for repair and immune regulation.
How similar studies have performed: Some early clinical trials have tested MSC-derived exosomes for brain repair, but controlling exosome production and cargo is still a novel and developing area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Jeong, Sangmoo — Johns Hopkins University
- Study coordinator: Jeong, Sangmoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.