How Cell Metabolism Changes to Produce Molecules Linked to Heart Disease
Metabolic rewiring coupled to the production of reactive oxygen and nitrogen species (RONS)
This research explores how our cells change their energy use to create certain molecules, called RONS, which play a role in conditions like heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morgridge Institute for Research, INC. NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11142636 on NIH RePORTER |
What this research studies
Our bodies naturally produce reactive oxygen and nitrogen species (RONS), which are important for normal cell functions but can also contribute to diseases like heart conditions when out of balance. This project aims to understand how cells adjust their metabolism, or how they use energy, to produce these RONS molecules. Researchers are particularly interested in how cells meet the high energy demands for RONS production, such as by shifting to a special way of processing glucose. By uncovering these fundamental processes, we hope to learn more about how RONS contribute to disease and how we might better manage them.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but could eventually benefit individuals with cardiovascular diseases and inflammatory disorders.
Not a fit: Patients without conditions related to reactive oxygen and nitrogen species production may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of cardiovascular diseases and potentially new ways to target the metabolic processes that contribute to them.
How similar studies have performed: The researchers have recently made discoveries in how immune cells manage energy for RONS production, suggesting a novel approach to this area of study.
Where this research is happening
Madison, United States
- Morgridge Institute for Research, INC. — Madison, United States (Active)
Researchers
- Principal investigator: Fan, Jing — Morgridge Institute for Research, INC.
- Study coordinator: Fan, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.