How cell metabolism affects bone regeneration after injury
Cellular metabolism at the crossroads of skeletal regeneration
This study is looking at how the body's energy use affects healing after limb injuries, like amputations, especially as we get older, to find new ways to help people heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10847421 on NIH RePORTER |
What this research studies
This research investigates the role of cellular metabolism in the process of skeletal regeneration, particularly after limb injuries such as amputations. Using a mouse model, the study examines how aging impacts the regeneration of bone and the underlying metabolic and genetic mechanisms involved. The researchers aim to understand how manipulating metabolic pathways and gene expression can enhance bone regeneration, potentially leading to new therapeutic strategies for patients with impaired healing. By exploring the effects of specific metabolites and genetic factors, the research seeks to fill a significant knowledge gap in regenerative medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with bone injuries or conditions that impair bone healing, particularly older adults.
Not a fit: Patients with non-bone related injuries or conditions that do not affect skeletal regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with bone injuries, enhancing their healing and recovery processes.
How similar studies have performed: Other research has shown promising results in manipulating metabolic pathways to enhance regeneration, suggesting that this approach could be effective.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sammarco, Mimi C — Mayo Clinic Rochester
- Study coordinator: Sammarco, Mimi C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.