How cell membrane composition affects appetite-regulating receptors
Impact of membrane composition on cholecystokinin receptor structure and function
This study is looking at how the makeup of cell membranes affects a specific receptor that helps control hunger and feelings of fullness, with the goal of finding better and safer treatments for obesity, especially for those who haven't had success with current options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10984483 on NIH RePORTER |
What this research studies
This research investigates how the composition of cell membranes influences the structure and function of cholecystokinin type 1 receptors (CCK1Rs), which play a crucial role in regulating feelings of fullness and appetite. By understanding the relationship between membrane cholesterol and receptor activity, the study aims to develop safer and more effective treatments for obesity. The research will explore innovative methods for drug targeting that could enhance the therapeutic potential of CCK1R drugs, particularly for individuals who do not respond well to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity, particularly those who have not responded to existing appetite-regulating medications.
Not a fit: Patients who are not affected by obesity or those who do not have issues with appetite regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved obesity treatments that are more effective and have fewer side effects.
How similar studies have performed: Previous research has shown promise in targeting similar receptors for appetite regulation, suggesting that this approach could yield significant advancements in obesity treatment.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Miller, Laurence J — Mayo Clinic Arizona
- Study coordinator: Miller, Laurence J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.