How cell mechanics affect the development of the neural tube
Mechanisms of mechanotransduction during neural tube morphogenesis
This study looks at how the way cells move and work together helps shape the spinal cord during development, which is important for preventing birth defects like neural tube defects, and it uses special techniques in mice to learn more about these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10862609 on NIH RePORTER |
What this research studies
This research investigates the role of actomyosin contractility in shaping cells and tissues during the development of the neural tube, which is crucial for proper spinal cord formation. By examining how mechanical forces influence cell behavior and signaling pathways, the study aims to uncover the underlying mechanisms that can lead to birth defects like neural tube defects. The research employs advanced techniques such as live imaging and genetic manipulation in mouse models to explore these processes in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of neural tube defects or other related congenital anomalies.
Not a fit: Patients who do not have a genetic predisposition to neural tube defects or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for preventing neural tube defects and other related birth defects.
How similar studies have performed: Other research has shown success in understanding the role of mechanical forces in development, making this approach both relevant and promising.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Lu, Xiaowei — University of Virginia
- Study coordinator: Lu, Xiaowei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.