How cell lineage affects immune response in neuroblastoma
Cell lineage as an indicator of immune response in neuroblastoma
This study is looking at how different types of cells in neuroblastoma tumors affect how well kids respond to immune treatments, with the goal of finding better ways to personalize their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11079472 on NIH RePORTER |
What this research studies
This research investigates the relationship between cell lineage and immune response in neuroblastoma, a type of cancer primarily affecting children. By analyzing genetic signatures from tumor samples, the study aims to identify which cell types are more likely to respond to immune therapies. The researchers will focus on understanding the mechanisms that lead to varying responses to treatments like adoptive immunotherapy. This could help tailor more effective treatment strategies for patients based on their tumor characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neuroblastoma, particularly those with specific tumor characteristics related to immune response.
Not a fit: Patients with neuroblastoma who do not have the specific tumor characteristics being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immune-based therapies for children with neuroblastoma.
How similar studies have performed: Previous research has shown promise in using genetic signatures to predict responses to immunotherapy, suggesting that this approach could be beneficial.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: George, Rani E. — Dana-Farber Cancer Inst
- Study coordinator: George, Rani E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.