How cell identity factors control the growth of blood cells during their development
Official title: The direct transcriptional regulation of cell cycle genes by cell identity factors during myeloid differentiation
Funded at University of North Dakota · NIH-10974733 · Data updated 2026-11-12
This study is looking at how certain proteins help blood cells grow and mature, especially in conditions like acute myeloid leukemia, to better understand how these cells stop dividing and become fully developed.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Dakota NIH-funded |
| Lab location | 1 site (Grand Forks, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $423,000 |
| NIH project number | 1R15HL172092-01A1 |
| Project ID | NIH-10974733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia or related blood disorders.
✕Less likely to help
Patients with solid tumors or non-hematological conditions may not benefit from this research.
What this research studies
This research investigates how specific proteins, known as transcription factors, influence the growth and differentiation of blood cells, particularly during the development of myeloid cells. It focuses on understanding the mechanisms that lead to the exit of these cells from the cell cycle, which is crucial for their maturation. By using laboratory models, the study will explore how these factors regulate genes that control cell division and differentiation, potentially revealing new insights into blood cancers like acute myeloid leukemia. The research employs advanced techniques to analyze gene expression and DNA accessibility during this process.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating blood cancers by targeting the mechanisms that control cell growth and differentiation.
How similar studies have gone: Previous research has shown promising results in understanding cell cycle regulation in blood cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of North Dakota
Grand Forks, United States Active
Researchers
- Principal investigator: Manu, Manu — University of North Dakota
- Study coordinator: Manu, Manu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.