How cell growth and metabolism are controlled during different phases of the cell cycle
Official title: Cell cycle control of cellular metabolism through phase-specific regulation of mTOR Complex 1
Funded at Rutgers Biomedical and Health Sciences · NIH-11124872 · Data updated 2026-11-12
This study is looking at how a key protein called mTORC1 affects the way cells use energy during different stages of cell division, which could help us understand how this process relates to diseases that involve cell growth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $392,500 |
| NIH project number | 5R35GM155379-02 |
| Project ID | NIH-11124872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal cell growth or proliferation, such as cancer patients.
✕Less likely to help
Patients with stable, non-proliferative conditions or those not experiencing issues related to cell cycle regulation may not benefit from this research.
What this research studies
This research investigates the relationship between cell cycle phases and cellular metabolism, focusing on how the mTOR Complex 1 (mTORC1) regulates metabolic processes at different stages of cell division. By tracking mTORC1 activity throughout the cell cycle, the study aims to uncover how metabolic demands change and how these changes influence cell growth and proliferation. The approach involves detailed analysis of metabolic pathways and their regulation by mTORC1, which is crucial for understanding the underlying mechanisms of various human diseases related to cell growth.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how to manipulate cell growth and metabolism, potentially improving treatments for diseases such as cancer.
How similar studies have gone: While the specific approach of examining mTORC1's role across different cell cycle phases is novel, related research has shown that targeting metabolic pathways can significantly impact treatment outcomes in various diseases.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Valvezan, Alexander — Rutgers Biomedical and Health Sciences
- Study coordinator: Valvezan, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.