How cell and matrix interactions affect aortic diseases
Official title: Dynamic Cell-Matrix Interactions Dictate Thoracic Aortopathy
Funded at Yale University · NIH-11015430 · Data updated 2026-11-12
This study is looking at how certain genes and conditions like high blood pressure can change the aorta's structure and function, using mice to help us learn more about its strength and how to better treat problems like aneurysms.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $358,300 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of aortic diseases or those diagnosed with conditions that affect the aorta.
✕Less likely to help
Patients with no genetic predisposition to aortic diseases or those without relevant risk factors may not benefit from this research.
What this research studies
This research investigates how changes in cell signaling and gene expression, influenced by genetic variants and conditions like hypertension, affect the structure and function of the aorta. By using advanced biomechanical testing and machine learning, the study aims to quantify the biomechanical properties of the aorta, which can indicate its vulnerability to serious conditions such as aneurysms. The research will involve testing various mouse models to gather comprehensive data that can lead to better understanding and treatment of thoracic aortopathy.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating aortic diseases, potentially reducing the risk of life-threatening complications.
How similar studies have gone: Previous research has shown promise in understanding aortic diseases through biomechanical analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Humphrey, Jay D. — Yale University
- Study coordinator: Humphrey, Jay D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.