How cell and matrix interactions affect aortic diseases
Dynamic Cell-Matrix Interactions Dictate Thoracic Aortopathy
['FUNDING_P01'] · YALE UNIVERSITY · NIH-11015430
This study is looking at how certain genes and conditions like high blood pressure can change the aorta's structure and function, using mice to help us learn more about its strength and how to better treat problems like aneurysms.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11015430 on ClinicalTrials.gov |
What this research studies
This research investigates how changes in cell signaling and gene expression, influenced by genetic variants and conditions like hypertension, affect the structure and function of the aorta. By using advanced biomechanical testing and machine learning, the study aims to quantify the biomechanical properties of the aorta, which can indicate its vulnerability to serious conditions such as aneurysms. The research will involve testing various mouse models to gather comprehensive data that can lead to better understanding and treatment of thoracic aortopathy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of aortic diseases or those diagnosed with conditions that affect the aorta.
Not a fit: Patients with no genetic predisposition to aortic diseases or those without relevant risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating aortic diseases, potentially reducing the risk of life-threatening complications.
How similar studies have performed: Previous research has shown promise in understanding aortic diseases through biomechanical analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUMPHREY, JAY D. — YALE UNIVERSITY
- Study coordinator: HUMPHREY, JAY D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic Diseases, aortic disorder