How cell adhesion affects the production of small vesicles in cancer cells
Regulation of extracellular vesicle biogenesis through cell adhesion
This study is looking at how cancer cells stick together and how that affects tiny particles they release, which could help us understand how bladder cancer spreads and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11045664 on NIH RePORTER |
What this research studies
This research investigates the relationship between cell adhesion and the production of extracellular vesicles (EVs) in cancer cells, particularly focusing on bladder cancer. By examining how the shedding of adhesion receptors influences EV biogenesis, the study aims to uncover new mechanisms that drive cancer metastasis. The researchers will utilize advanced laboratory techniques to manipulate and observe these processes in cancer cell lines, providing insights into how these cellular behaviors are interconnected. This could lead to a better understanding of cancer progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with bladder cancer or those at risk of cancer metastasis.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer metastasis, improving treatment outcomes for patients.
How similar studies have performed: Other research has shown promising results in understanding the role of cell adhesion in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Pua, Heather H — Vanderbilt University Medical Center
- Study coordinator: Pua, Heather H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.