How CDKs control cell division and gene activity
Cyclin-dependent kinase control of cell-division and transcription cycles
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11290434
This project looks at how enzymes called CDKs and partner phosphatases control gene activity and cell division in ways that matter for cancer patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11290434 on ClinicalTrials.gov |
What this research studies
Researchers at Mount Sinai use lab-grown cells and precise genetic changes to see how CDKs and phosphatases add or remove chemical marks on the molecular machines that make RNA. They will lock specific phosphatases into permanently on or off states and map genome-wide effects on RNA polymerase II behavior and gene expression. The team will also test small molecules that might disrupt these switches to see if they change gene activity or slow cell growth. The goal is to reveal molecular switches that could become targets for new cancer treatments.
Who could benefit from this research
Good fit: Patients whose tumors show abnormal CDK or transcriptional regulation could be candidates for future trials based on these findings.
Not a fit: People with non-cancer conditions or cancers not driven by CDK/transcriptional changes are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could identify new drug targets to block cancer growth by disrupting key CDK–phosphatase switches.
How similar studies have performed: Some CDK-targeting drugs are already approved for cancer, but targeting transcriptional CDKs and the specific phosphatase switches here is a newer approach still at the preclinical stage.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FISHER, ROBERT P — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FISHER, ROBERT P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment, Cancers