How cardiovascular genetics and APOE ε4 status affect amyloid levels in early Alzheimer's disease
Cardiovascular Genotype and APOE ε4 Carrier Status Interaction Effects on Amyloid Load in Pre-Clinical Alzheimer's Disease
This study is looking at how certain genes and the presence of the APOE ε4 gene might affect the buildup of amyloid plaques in people who are at risk for Alzheimer's disease, especially those with conditions like high cholesterol and high blood pressure, to see if there are ways to protect against Alzheimer's.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Banner Health NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project ID | NIH-10849838 on NIH RePORTER |
What this research studies
This research investigates the interaction between cardiovascular genetic factors and APOE ε4 carrier status in relation to amyloid load in individuals with pre-clinical Alzheimer's disease. It aims to understand how conditions like high cholesterol and hypertension may influence the development of Alzheimer's pathology, particularly the formation of amyloid plaques. By analyzing specific genetic markers, the study seeks to uncover potential protective factors against amyloid deposition and their implications for Alzheimer's risk. Patients may undergo genetic testing and assessments to determine their eligibility and potential involvement in the research.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults who are APOE ε4 carriers and may have cardiovascular risk factors.
Not a fit: Patients who do not have pre-clinical Alzheimer's disease or are not APOE ε4 carriers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for preventing or delaying Alzheimer's disease in at-risk individuals.
How similar studies have performed: Previous studies have shown promising results in understanding the relationship between cardiovascular health and Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
Phoenix, United States
- Banner Health — Phoenix, United States (Active)
Researchers
- Principal investigator: Malek-Ahmadi, Michael — Banner Health
- Study coordinator: Malek-Ahmadi, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.