How cardiovascular genetics and APOE ε4 status affect amyloid levels in early Alzheimer's disease

Who could benefit from this research

What this research studies

This research investigates the interaction between cardiovascular genetic factors and APOE ε4 carrier status in relation to amyloid load in individuals with pre-clinical Alzheimer's disease. It aims to understand how conditions like high cholesterol and hypertension may influence the development of Alzheimer's pathology, particularly the formation of amyloid plaques. By analyzing specific genetic markers, the study seeks to uncover potential protective factors against amyloid deposition and their implications for Alzheimer's risk. Patients may undergo genetic testing and assessments to determine their eligibility and potential involvement in the research.

Why it matters

Where this research is happening

• Banner Health
  Phoenix, United States Active

Researchers

• Principal investigator: Malek-Ahmadi, Michael — Banner Health
• Study coordinator: Malek-Ahmadi, Michael

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.