How cannabis use during adolescence affects brain function and behavior

Impact of Cannabinoid Across the Lifespan (ICAL)

NIH-funded research University of California-Irvine · NIH-11120992

This study looks at how using cannabis during the teenage years affects the brain and behavior, helping us understand the potential risks of cannabis for young people.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of California-Irvine NIH-funded
Lab location1 site (Irvine, United States)
Project IDNIH-11120992 on NIH RePORTER

What this research studies

This research investigates the effects of cannabis use during adolescence on the endocannabinoid signaling system, which is crucial for brain function and behavior. By using a combination of molecular, synaptic, and behavioral approaches, the study aims to understand how early exposure to THC, the active component in cannabis, can lead to long-lasting changes in cognition and motivation. The research involves animal models to simulate adolescent cannabis use patterns and assess the resulting biological and behavioral changes. The findings could provide insights into the risks associated with adolescent cannabis consumption.

Who could benefit from this research

Good fit: Ideal candidates for participation or benefit from this research include adolescents and young adults who have used cannabis or are considering its use.

Not a fit: Patients who have not used cannabis or are outside the adolescent and young adult age range may not receive direct benefits from this research.

Why it matters

Potential benefit: If successful, this research could help inform guidelines and interventions to mitigate the negative effects of adolescent cannabis use on brain development and mental health.

How similar studies have performed: Previous research has shown that early cannabis exposure can lead to significant changes in brain function, suggesting that this study builds on established findings in the field.

Where this research is happening

Irvine, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.