How cannabinoids affect the blood-brain barrier in people with HIV
The role of cannabinoids in the regulation of the blood brain barrier in the context of NeuroHIV and anti-retroviral therapy
This study is looking at how THC and CBD, two compounds found in cannabis, might help improve brain health and reduce inflammation in people living with HIV, especially those on treatment, to find new ways to tackle related brain problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11012273 on NIH RePORTER |
What this research studies
This research investigates the impact of cannabinoids, specifically THC and CBD, on the blood-brain barrier (BBB) in individuals living with HIV. It aims to understand how these compounds can influence chronic inflammation and neurocognitive complications associated with HIV, especially in the context of antiretroviral therapy. Using advanced microfluidic models and animal studies, the research will explore the mechanisms by which cannabinoids may improve BBB function and immune responses. The findings could provide insights into new therapeutic strategies for managing HIV-related neurological issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who experience neurocognitive complications despite antiretroviral therapy.
Not a fit: Patients who do not have HIV or those who are not experiencing neurocognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neurocognitive complications in people living with HIV.
How similar studies have performed: Previous research has shown promising results regarding the effects of cannabinoids on inflammation and neurological conditions, suggesting potential for success in this area.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Persidsky, Yuri — Temple Univ of the Commonwealth
- Study coordinator: Persidsky, Yuri
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.