How cannabinoids affect inflammation in HIV-related brain disorders
Epigenetic mechanisms underlying cannabinoid modulation of neuroinflammation in HIV/SIV infection
This study is looking at how cannabis compounds might help reduce brain inflammation and improve thinking skills in people living with HIV by exploring how they affect genes related to inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10884276 on NIH RePORTER |
What this research studies
This research investigates the role of cannabinoids in modulating neuroinflammation associated with HIV infection. It focuses on understanding the epigenetic mechanisms, particularly DNA methylation, that may contribute to neurological disorders in HIV patients. By studying the effects of cannabinoids on brain inflammation and gene expression, the research aims to uncover potential therapeutic strategies for improving cognitive function in affected individuals. The approach includes both animal models and molecular analysis to explore these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing neurological symptoms such as memory issues or cognitive decline.
Not a fit: Patients who do not have HIV or those without neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and reduce neuroinflammation in patients with HIV-associated neurological disorders.
How similar studies have performed: Previous research has shown promising results in using cannabinoids to modulate inflammation in other neurological conditions, suggesting potential success in this area as well.
Where this research is happening
San Antonio, United States
- Texas Biomedical Research Institute — San Antonio, United States (Active)
Researchers
- Principal investigator: Mohan, Mahesh — Texas Biomedical Research Institute
- Study coordinator: Mohan, Mahesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.