How cannabinoids affect cell communication in HIV infection
Cannabinoid modulation of EV composition and function in HIV/SIV infection
['FUNDING_R01'] · NEW YORK MEDICAL COLLEGE · NIH-10693315
This study looks at how THC, a compound found in cannabis, affects tiny particles that help cells communicate in the body during HIV infection, and it's especially for people living with HIV who use cannabis to feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK MEDICAL COLLEGE (nih funded) |
| Locations | 1 site (VALHALLA, UNITED STATES) |
| Trial ID | NIH-10693315 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cannabinoids, specifically delta-9-tetrahydrocannabinol (THC), in modifying the composition and function of extracellular vesicles (EVs) during HIV/SIV infection. By focusing on the gastrointestinal tract and peripheral lymph nodes in a SIV-rhesus macaque model, the study aims to understand how THC influences intercellular communication and immune responses in HIV-infected individuals. The research is particularly relevant for patients who use cannabis to manage symptoms associated with HIV and its treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-infected individuals, particularly those who also use cannabis for symptom relief.
Not a fit: Patients who are not HIV-infected or do not use cannabis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for managing HIV infection and its associated complications.
How similar studies have performed: Previous research has shown that cannabinoids can have beneficial effects on inflammation and immune activation in HIV patients, suggesting potential for success in this area.
Where this research is happening
VALHALLA, UNITED STATES
- NEW YORK MEDICAL COLLEGE — VALHALLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OKEOMA, CHIOMA M — NEW YORK MEDICAL COLLEGE
- Study coordinator: OKEOMA, CHIOMA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.