How cannabinoids affect cell communication in HIV infection
Official title: Cannabinoid modulation of EV composition and function in HIV/SIV infection
Funded at New York Medical College · NIH-10693315 · Data updated 2026-11-12
This study looks at how THC, a compound found in cannabis, affects tiny particles that help cells communicate in the body during HIV infection, and it's especially for people living with HIV who use cannabis to feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $784,694 |
| NIH project number | 5R01DA050169-05 |
| Project ID | NIH-10693315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are HIV-infected individuals, particularly those who also use cannabis for symptom relief.
✕Less likely to help
Patients who are not HIV-infected or do not use cannabis may not benefit from this research.
What this research studies
This research investigates the role of cannabinoids, specifically delta-9-tetrahydrocannabinol (THC), in modifying the composition and function of extracellular vesicles (EVs) during HIV/SIV infection. By focusing on the gastrointestinal tract and peripheral lymph nodes in a SIV-rhesus macaque model, the study aims to understand how THC influences intercellular communication and immune responses in HIV-infected individuals. The research is particularly relevant for patients who use cannabis to manage symptoms associated with HIV and its treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for managing HIV infection and its associated complications.
How similar studies have gone: Previous research has shown that cannabinoids can have beneficial effects on inflammation and immune activation in HIV patients, suggesting potential for success in this area.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Okeoma, Chioma M — New York Medical College
- Study coordinator: Okeoma, Chioma M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.