How cannabinoids affect brain development in children
Cannabinoid Signaling Interactions During Axon Development in situ
['FUNDING_R15'] · TOURO UNIVERSITY OF CALIFORNIA · NIH-10654243
This study is looking at how cannabinoids from cannabis might affect brain development in babies who were exposed to them before birth, using a frog model to understand how these substances influence the way brain connections form during important growth stages.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TOURO UNIVERSITY OF CALIFORNIA (nih funded) |
| Locations | 1 site (VALLEJO, UNITED STATES) |
| Trial ID | NIH-10654243 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of cannabinoids, found in cannabis, on the development of the brain, particularly focusing on how these substances may influence the formation of neuronal circuits in children exposed to them in utero. Using a frog model that shares genetic similarities with humans, the study aims to explore the mechanisms by which cannabinoid receptors affect brain structure and function during critical developmental stages. The researchers will analyze how these receptors interact with other molecular factors to regulate the growth and pathfinding of axons, which are essential for proper brain connectivity.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who use cannabis and their children, particularly those exposed to cannabinoids during pregnancy.
Not a fit: Patients who have not been exposed to cannabinoids during pregnancy or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the risks associated with cannabis use during pregnancy and inform guidelines to protect children's cognitive and behavioral health.
How similar studies have performed: Previous studies in animal models have shown significant insights into cannabinoid signaling, suggesting that this research could build on established findings, although the specific focus on human-like neuronal circuit formation remains novel.
Where this research is happening
VALLEJO, UNITED STATES
- TOURO UNIVERSITY OF CALIFORNIA — VALLEJO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELUL, TAMIRA — TOURO UNIVERSITY OF CALIFORNIA
- Study coordinator: ELUL, TAMIRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.