How cannabinoid receptors affect learning and memory in the brain
Official title: CB1 receptors mediate metaplasticity in the cerebellar circuit
Funded at University of Texas Hlth Science Center · NIH-11045648 · Data updated 2026-11-12
This study is looking at how certain brain receptors help with learning and memory, which could lead to new ways to support people with Alzheimer's and other memory issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | March 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $354,445 |
| NIH project number | 5R01NS131652-02 |
| Project ID | NIH-11045648 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or related cognitive impairments.
✕Less likely to help
Patients with non-cognitive related neurological disorders may not receive benefits from this research.
What this research studies
This research investigates the role of type 1 cannabinoid receptors (CB1 receptors) in regulating synaptic plasticity, which is essential for learning and memory in the cerebellar circuit of the brain. The researchers will use advanced techniques like 2-photon microscopy to observe how changes in CB1 receptor expression influence the strength of synapses during learning processes. By understanding these mechanisms, the study aims to uncover how the brain adapts and stores information, particularly in relation to conditions like Alzheimer's disease. Patients may benefit from insights that could lead to new therapeutic strategies for cognitive impairments.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance learning and memory in patients with cognitive disorders.
How similar studies have gone: Previous research has shown promising results in understanding synaptic plasticity and cannabinoid receptors, indicating potential for significant advancements in this area.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Pugh, Jason Richard — University of Texas Hlth Science Center
- Study coordinator: Pugh, Jason Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.