How cannabinoid receptors affect learning and memory in the brain
CB1 receptors mediate metaplasticity in the cerebellar circuit
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11045648
This study is looking at how certain brain receptors help with learning and memory, which could lead to new ways to support people with Alzheimer's and other memory issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11045648 on ClinicalTrials.gov |
What this research studies
This research investigates the role of type 1 cannabinoid receptors (CB1 receptors) in regulating synaptic plasticity, which is essential for learning and memory in the cerebellar circuit of the brain. The researchers will use advanced techniques like 2-photon microscopy to observe how changes in CB1 receptor expression influence the strength of synapses during learning processes. By understanding these mechanisms, the study aims to uncover how the brain adapts and stores information, particularly in relation to conditions like Alzheimer's disease. Patients may benefit from insights that could lead to new therapeutic strategies for cognitive impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or related cognitive impairments.
Not a fit: Patients with non-cognitive related neurological disorders may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance learning and memory in patients with cognitive disorders.
How similar studies have performed: Previous research has shown promising results in understanding synaptic plasticity and cannabinoid receptors, indicating potential for significant advancements in this area.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PUGH, JASON RICHARD — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: PUGH, JASON RICHARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease