How cannabinoid receptors affect kidney function and urine output
The regulation of renal tubular transport by cannabinoid receptor type 1 (CB1R) and its endogenous lipid ligands
['FUNDING_OTHER'] · JAMES J PETERS VA MEDICAL CENTER · NIH-10866340
This study is looking at how a specific receptor in the kidneys, called CB1R, affects urine production and the balance of important minerals like sodium and potassium, which could help find new ways to treat kidney problems for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JAMES J PETERS VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-10866340 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cannabinoid receptor type 1 (CB1R) in the kidneys, particularly how it influences urine production and the balance of sodium and potassium. The study will explore the expression of endogenous cannabinoids in kidney cells and their effects on kidney function using mouse models. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for kidney-related conditions. Patients may benefit from insights into how cannabinoids can be used to manage kidney function and fluid balance.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be adults over 21 years old with kidney-related health issues.
Not a fit: Patients with non-renal conditions or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for kidney disorders by utilizing cannabinoid signaling to regulate urine output and electrolyte balance.
How similar studies have performed: While cannabinoid effects on kidney function have been observed in animal models, this specific approach in humans is relatively novel and has not been extensively tested.
Where this research is happening
BRONX, UNITED STATES
- JAMES J PETERS VA MEDICAL CENTER — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REIN, JOSHUA L — JAMES J PETERS VA MEDICAL CENTER
- Study coordinator: REIN, JOSHUA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.