How cannabinoid receptors affect kidney function and urine output
Official title: The regulation of renal tubular transport by cannabinoid receptor type 1 (CB1R) and its endogenous lipid ligands
Funded at James J Peters VA Medical Center · NIH-10866340 · Data updated 2026-11-12
This study is looking at how a specific receptor in the kidneys, called CB1R, affects urine production and the balance of important minerals like sodium and potassium, which could help find new ways to treat kidney problems for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 5IK2BX006144-02 |
| Project ID | NIH-10866340 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be adults over 21 years old with kidney-related health issues.
✕Less likely to help
Patients with non-renal conditions or those under 21 years old may not receive any benefit from this research.
What this research studies
This research investigates the role of cannabinoid receptor type 1 (CB1R) in the kidneys, particularly how it influences urine production and the balance of sodium and potassium. The study will explore the expression of endogenous cannabinoids in kidney cells and their effects on kidney function using mouse models. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for kidney-related conditions. Patients may benefit from insights into how cannabinoids can be used to manage kidney function and fluid balance.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for kidney disorders by utilizing cannabinoid signaling to regulate urine output and electrolyte balance.
How similar studies have gone: While cannabinoid effects on kidney function have been observed in animal models, this specific approach in humans is relatively novel and has not been extensively tested.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Rein, Joshua L — James J Peters VA Medical Center
- Study coordinator: Rein, Joshua L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.