How cannabidiol affects HIV and brain inflammation in mice
Mechanism of Cannabidiol Effects on HIV Expression, Neuroinflammation, and HIV Cognitive Disease in Chronically-infected Immunocompetent Mice
This study is looking at how cannabidiol (CBD) might affect HIV and brain inflammation in mice with chronic HIV infection, to see if it could help improve immune response and brain health for people dealing with HIV-related cognitive issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10896974 on NIH RePORTER |
What this research studies
This research investigates the effects of cannabidiol (CBD) on HIV expression and neuroinflammation in mice that are chronically infected with HIV. The study aims to understand how CBD may influence the immune response and the progression of HIV-related cognitive diseases. By using various behavioral tests and examining brain tissue, researchers will assess whether CBD has beneficial or harmful effects on HIV control and brain health. This research could provide insights into the complex interactions between CBD and HIV in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be experiencing cognitive issues or neuroinflammation.
Not a fit: Patients who are not living with HIV or those who do not have cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how CBD impacts HIV-related cognitive diseases and potentially inform treatment strategies for people living with HIV.
How similar studies have performed: While there is ongoing research into the effects of cannabinoids on HIV, this specific approach examining the interplay between CBD and HIV in the brain is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Volsky, David J — Icahn School of Medicine at Mount Sinai
- Study coordinator: Volsky, David J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.