How Candida can protect against severe infections caused by bacteria
Candida mediated protection against polymicrobial sepsis
This study is looking at how a common fungus, Candida albicans, might help protect against serious bacterial infections in people who are very sick, especially when another fungus, Candida dubliniensis, is also present, and it could lead to new treatments for those battling severe infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10583504 on NIH RePORTER |
What this research studies
This research investigates the role of the fungus Candida albicans in providing protection against severe infections caused by bacteria, particularly in cases of polymicrobial sepsis. The study uses an animal model to explore how co-infection with another fungus, Candida dubliniensis, can lead to a significant reduction in mortality rates from these infections. The researchers are particularly interested in understanding the mechanisms behind this protective effect, which appears to involve trained innate immunity rather than adaptive immunity. This could lead to new therapeutic strategies for patients suffering from severe infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients at high risk for polymicrobial sepsis, particularly those with invasive fungal infections.
Not a fit: Patients who do not have a history of severe infections or those with non-fungal related infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the body's natural defenses against life-threatening infections.
How similar studies have performed: Other research has shown promising results in using similar approaches to enhance immune responses, indicating potential for success in this area.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Steele, Chad — Tulane University of Louisiana
- Study coordinator: Steele, Chad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.