How cancer-related genes affect cell aging and survival in melanoma.
Official title: The Oncogene Activated Mitochondrial Unfolded Protein Response Regulates Senescence Biology
Funded at Icahn School of Medicine at Mount Sinai · NIH-11057584 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria affect cancer, especially in melanoma, by exploring how certain genes influence aging and survival in skin cells, with the hope of finding new ways to prevent or treat early stages of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 3, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $552,538 |
| NIH project number | 5R01CA271346-03 |
| Project ID | NIH-11057584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with pre-malignant skin lesions or those at high risk for developing melanoma.
✕Less likely to help
Patients with advanced melanoma or those who do not have any pre-malignant conditions may not benefit from this research.
What this research studies
This research investigates the role of mitochondria in cancer cell biology, particularly focusing on how specific oncogenes influence cellular processes related to aging and survival in melanoma. By studying primary human melanocytes and utilizing patient data, the research aims to uncover the mechanisms that lead to early stages of cancer development. The approach includes both laboratory experiments and analysis of patient tissues to understand how these processes can be targeted for therapeutic benefit. The findings could provide insights into the biology of pre-malignant conditions and potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating melanoma by targeting the cellular mechanisms that drive cancer progression.
How similar studies have gone: Previous research has shown promising results in understanding the role of mitochondria in cancer biology, suggesting that this approach could yield valuable insights.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Chipuk, Jerry Edward — Icahn School of Medicine at Mount Sinai
- Study coordinator: Chipuk, Jerry Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.