How cancer cells use exosomes to spread and resist treatment.
Metabolic regulation of exosome biogenesis as a determinant of cancer cell metastasis.
This study is looking at how aggressive breast cancer cells make tiny particles called exosomes that can affect how the cancer grows and spreads, focusing on a specific protein and a nutrient to see how they play a role in this process, which could help find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11009522 on NIH RePORTER |
What this research studies
This research investigates how aggressive breast cancer cells produce exosomes, which are tiny vesicles that can influence cancer progression and metastasis. By examining the role of a protein called SIRT1 and the metabolism of glutamine in these cells, the study aims to understand how these factors contribute to the generation of exosomes and their unique contents. The research employs advanced cell culture techniques to analyze the behavior of cancer cells and their secreted exosomes, providing insights into potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with aggressive breast cancer, particularly those experiencing metastasis.
Not a fit: Patients with non-aggressive forms of breast cancer or those without a current diagnosis of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing breast cancer metastasis and improving treatment responses.
How similar studies have performed: Other research has shown promising results in understanding the role of exosomes in cancer, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Antonyak, Marc a — Cornell University
- Study coordinator: Antonyak, Marc a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.