How Cancer Cells Move in Tight Spaces
Molecular Mechanisms of Confined Cell Migration
This project explores how cancer cells and immune cells move through crowded body tissues, which is important for understanding how cancer spreads.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-11109516 on NIH RePORTER |
What this research studies
Our bodies have many different environments, and cells need to adapt how they move to get around. When cells are in very tight spaces, like within a tumor, they can switch to a fast, "amoeboid" way of moving, using a special "leader bleb." This research aims to uncover the exact molecular steps that both cancer cells and immune cells use to make this switch and move in these confined areas. By understanding these mechanisms, we hope to find new ways to stop cancer from spreading.
Who could benefit from this research
Good fit: This foundational laboratory research is relevant for patients with various types of cancer, especially those concerned about metastasis.
Not a fit: Patients not affected by cancer or conditions involving cell migration would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to prevent cancer cells from spreading throughout the body.
How similar studies have performed: Previous work has shown that certain proteins are essential for this type of cell movement, and this project builds upon those findings to uncover more detailed mechanisms.
Where this research is happening
Albany, United States
- Albany Medical College — Albany, United States (Active)
Researchers
- Principal investigator: Logue, Jeremy S — Albany Medical College
- Study coordinator: Logue, Jeremy S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.